Geordi: Under the influence of the virus, Geordi laments his blindness and tells Tasha that he wants to see like she does.It is a mutated form of a virus that infected the crew of the original Enterprise. Tsiolkovsky Virus: The Enterprise crew is infected with a virus where complex strains of water molecules acquired carbon from the body and acted on the brain like alcohol.There is no Alien of the Week in this episode.Data replaces the chips and the Enterprise escapes. Crusher manages to use the old Enterprise's cure to create a cure for this new form of the virus, while Wesley turns the ship's tractor beam into a repulsor beam, pushing the Enterprise off the Tsiolkovsky and giving them the extra time they need. However, he informs the crew he will need a few minutes more than they have. Wesley suggests that Data could do it faster, so an infected Data sets out to get the engines back. However, it will take several hours for a human to replace the Isolinear chips.

Riker and Chief Engineer MacDougal manage to get past Wesley's forcefield and back into Engineering. The dilemma increases when a piece of the nearby collapsing star is sent hurtling towards the Enterprise. To make matters worse, an infected Wesley Crusher and Assistant Chief Engineer Shimoda block off Engineering, and Shimoda removes the Isolinear chips for the engines, rendering them non-functional. They discover something similar happened on the original Enterprise, and pass the information, including the cure used, to Dr. Riker recalls a record of someone showing in their clothes (which is how a member of Tsiolkovsky's crew was found), and asks Data to try to find it for him. Slowly, the entire crew becomes infected with the virus that caused the deaths of the Tsiolkovsky crew. Crusher confines him to sickbay, but he sneaks out while she's not looking. Crusher, Geordi starts behaving strangely. The away team returns to the episode, but while they are being examined by Dr. An away team beams over and discovers the crew are all dead, some frozen because of tampering with the environmental controls, while many were blown out into space when an emergency hatch on the bridge was blown.

Upon arriving at the Tsiolkovsky, the Enterprise receives a transmission, in which an explosion is heard. The Enterprise is sent to investigate why the USS Tsiolkovsky, a science vessel which is monitoring a collapsing star, has been sending strange messages back to Starfleet.

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